Rab GTPase-binding effector protein 1 (RABEP1) is a 862-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15276.
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The mean pLDDT of this model is 78.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A (PubMed:9323142). Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity)
Homodimer when bound to RAB5A (PubMed:15378032). Heterodimer with RABGEF1 (PubMed:11452015, PubMed:9323142). The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding (PubMed:10698684, PubMed:12773381, PubMed:20098723, PubMed:8521472). Interacts with TSC2 (PubMed:9045618). Interacts with GGA1 (via GAE domain), GGA2 (via GAE domain) and GGA3 (via GAE domain) (PubMed:12505986,…
Cytoplasm, Early endosome, Recycling endosome, Cytoplasmic vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1P4U | X-ray | 2.2 Å | B=435-447 |
| 4N3Y | X-ray | 2.2 Å | B/C=552-642 |
| 1TU3 | X-ray | 2.31 Å | F/G/H/I/J=789-862 |
| 1X79 | X-ray | 2.41 Å | B/C=551-661 |
| 4N3Z | X-ray | 3.1 Å | B/C=552-642 |
| 4Q9U | X-ray | 4.62 Å | C/D/G/H=552-642 |
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