Atypical chemokine receptor 1 (ACKR1) is a 336-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16570.
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The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May…
(Microbial infection) Interacts (via N-terminal extracellular domain) with Plasmodium vivax Duffy receptor (DBP) (via PvRII region)
Early endosome, Recycling endosome, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7P93 | X-ray | 1.55 Å | B/M=34-46 |
| 4NUU | X-ray | 1.95 Å | C=14-43 |
| 8A44 | X-ray | 2.49 Å | B=1-60 |
| 4NUV | X-ray | 2.6 Å | C/D=14-43 |
| 8JPS | EM | 3.65 Å | A/B=46-312 |
| 8YNF | EM | 3.65 Å | A/B=2-336 |
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