Frataxin, mitochondrial (FXN) is a 210-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16595.
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The mean pLDDT of this model is 75.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:12785837, PubMed:24971490). Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release (PubMed:24971490). Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (PubMed:29576242). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a…
Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is a heterohexamer containing two copies of each monomer (Probable). Homodimer (PubMed:31101807). Monomer (probable predominant form). Oligomer. Monomers and polymeric aggregates of >1 MDa have been isolated from mitochondria. A small fraction of heterologous…
Mitochondrion, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3T3L | X-ray | 1.15 Å | A=82-210 |
| 3T3K | X-ray | 1.24 Å | A=82-210 |
| 3S4M | X-ray | 1.3 Å | A=82-210 |
| 3S5E | X-ray | 1.31 Å | A=82-210 |
| 3T3T | X-ray | 1.38 Å | A/B/C/D=82-210 |
| 3S5D | X-ray | 1.5 Å | A=82-210 |
| 3S5F | X-ray | 1.5 Å | A/B=82-210 |
| 9HO5 | X-ray | 1.5 Å | A=90-210 |
| 3T3X | X-ray | 1.57 Å | A/B=82-210 |
| 3T3J | X-ray | 1.7 Å | A=82-210 |
| 9HO4 | X-ray | 1.76 Å | A=93-206 |
| 1EKG | X-ray | 1.8 Å | A=84-210 |
| 9HO6 | X-ray | 2.0 Å | A/B=90-210 |
| 8PK8 | EM | 2.49 Å | E=81-210 |
| 8RME | EM | 2.49 Å | I=81-210 |
| 8PK9 | EM | 2.58 Å | E=81-210 |
| 6NZU | EM | 3.2 Å | I/J=81-210 |
| 5KZ5 | EM | 14.3 Å | A/B/C/D/E/F/G/H/I/J/K/L=42-210 |
| 1LY7 | NMR | A=90-210 |
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