Auxilin (DNAJC6) is a 910-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q27974.
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The mean pLDDT of this model is 63.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
May act as a protein phosphatase and/or a lipid phosphatase (Probable). Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:11470803, PubMed:8524399). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion (PubMed:15023062, PubMed:15502813, PubMed:21482805, PubMed:7705342, PubMed:8524399). The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis…
Forms a complex composed of HSPA8, CLTC and DNAJC6 (PubMed:8524399). Interacts with HSPA8/HSC70 in an ATP-dependent manner; this interaction stimulates the HSPA8's ATPase activity (PubMed:12741832, PubMed:17996706). Interacts with CLTC; this interaction produces a local change in heavy-chain contacts, creating a detectable global distortion of the clathrin coat (PubMed:11470803, PubMed:15023062,…
Cytoplasmic vesicle, clathrin-coated vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QWO | X-ray | 1.7 Å | B=813-904 |
| 2QWP | X-ray | 1.75 Å | B=813-904 |
| 3N0A | X-ray | 2.2 Å | A=40-400 |
| 2QWQ | X-ray | 2.21 Å | B=813-904 |
| 2QWR | X-ray | 2.21 Å | B=813-904 |
| 2QWN | X-ray | 2.4 Å | B=812-905 |
| 1NZ6 | X-ray | 2.5 Å | A/B=810-910 |
| 1XI5 | EM | 12.0 Å | J/K/L/M/N/O/P/Q/R=797-910 |
| 1N4C | NMR | A=737-910 |
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