Unconventional myosin-VI (MYO6) is a 1254-residue protein from Sus scrofa. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q29122.
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The mean pLDDT of this model is 79.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 59% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (PubMed:15944696). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (PubMed:16917816). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized…
Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (PubMed:19664948, PubMed:25159143). Component of the DISP/DOCK7-induced septin displacement complex, at least composed of DOCK7, LRCH3 and MYO6 (By similarity). Able to function as a monomer under specific conditions in vitro (By similarity).…
Golgi apparatus, trans-Golgi network membrane, Golgi apparatus, Nucleus, Cytoplasm, perinuclear region, Membrane, clathrin-coated pit, Cytoplasmic vesicle, clathrin-coated vesicle, Cell projection, filopodium, Cell projection, ruffle membrane, Cell projection, microvillus, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2V26 | X-ray | 1.75 Å | A=5-789 |
| 4DBR | X-ray | 1.95 Å | A=5-790 |
| 2X51 | X-ray | 2.2 Å | A=1-816 |
| 3L9I | X-ray | 2.2 Å | A=2-816 |
| 4DBP | X-ray | 2.2 Å | A=2-816 |
| 5O2L | X-ray | 2.2 Å | A=5-790 |
| 2VB6 | X-ray | 2.3 Å | A=2-816 |
| 2BKH | X-ray | 2.4 Å | A=2-816 |
| 2VAS | X-ray | 2.4 Å | A=2-816 |
| 4ANJ | X-ray | 2.6 Å | A=1-818 |
| 4DBQ | X-ray | 2.6 Å | A=2-816 |
| 3GN4 | X-ray | 2.7 Å | A/E=771-918 |
| 2BKI | X-ray | 2.9 Å | A=1-859 |
| 6BNP | EM | 4.6 Å | I/J/K/L/M/N=2-706 |
| 6BNV | EM | 4.6 Å | I/J/K/L/M/N=2-818 |
| 6BNQ | EM | 5.5 Å | I/J/K/L/M/N=2-706 |
| 6BNW | EM | 5.5 Å | I/J/K/L/M/N=2-818 |
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