Leucotoxin LukEv (lukEv) is a 306-residue protein from Staphylococcus aureus (strain NCTC 8325 / PS 47). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q2FXB0.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin
Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes (By similarity). LukEv (class S) associates with LukDv (class F)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7P8X | X-ray | 1.4 Å | A=7-306 |
| 7P8T | X-ray | 1.46 Å | A=7-306 |
| 7P93 | X-ray | 1.55 Å | A=7-306 |
| 7P8U | X-ray | 1.6 Å | A=7-306 |
| 7P8S | X-ray | 1.9 Å | A=7-306 |
| 3ROH | X-ray | 3.2 Å | A=1-306 |
| 7T82 | X-ray | 3.5 Å | A/B=23-306 |
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