Viral IRF4-like protein (vIRF-4) is a 911-residue protein from Human herpesvirus 8 type P. This is its AlphaFold structure prediction, created 1 Jan 2024. UniProt accession: Q2HR73.
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The mean pLDDT of this model is 55.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 61% |
What pLDDT means and how to read it
Plays a role in host cell apoptosis modulation by promoting TP53/p53 ubiquitination and subsequent degradation and thus down-regulating TP53/p53-mediated apoptosis (PubMed:19369353). Works as a potential viral transcription factor to modulate host gene expression to build favorable environments for the viral lytic life cycle and greatly accelerates the induction of an immediate early gene RTA, early genes ORF36 and ORF57, late genes ORF25 and ORF64, and latent genes LANA1 and v-IRF3 (PubMed:24335298). Inhibits host interferon-alpha production by interacting with host IRF7 and preventing IRF7 dimerization (PubMed:28342865)
Interacts with host MDM2; this interaction facilitates the proteasomal degradation of TP53/p53 (PubMed:19369353). Interacts with host IRF7; this interaction prevents IRF7 dimerization and subsequent activation (PubMed:28342865)
Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2XXN | X-ray | 1.6 Å | B=202-216 |
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