R-spondin-1 (RSPO1) is a 263-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q2MKA7.
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The mean pLDDT of this model is 74.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt…
Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with ZNRF3; promoting indirect interaction between ZNRF3 and LGR4 and membrane clearance of ZNRF3. Interacts with LGR4, LGR5 and LGR6. Identified in a complex composed of RNF43, LGR5 and RSPO1. Interacts (via FU…
Secreted, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4BSP | X-ray | 2.0 Å | A=31-146 |
| 4BSO | X-ray | 2.2 Å | A=31-146 |
| 4QXF | X-ray | 2.25 Å | C/E=34-135 |
| 4KNG | X-ray | 2.5 Å | M/P=35-144 |
| 4KT1 | X-ray | 2.5 Å | E=39-128 |
| 4CDK | X-ray | 2.8 Å | E/F/G/H=31-145 |
| 4LI2 | X-ray | 3.19 Å | B=33-144 |
| 4BSR | X-ray | 3.2 Å | C/D=31-146 |
| 4BSS | X-ray | 3.2 Å | C/D/G/H=31-146 |
| 4BSU | X-ray | 3.2 Å | C/D/G/H=31-146 |
| 8WVU | EM | 3.61 Å | B=35-144 |
| 4BST | X-ray | 4.3 Å | C/D=31-146 |
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