Transient receptor potential cation channel subfamily M member 1 (Trpm1) is a 1622-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q2TV84.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (PubMed:19861548). In the dark, tonic release of glutamate activates the G protein-coupled receptor for glutamate (GRM6), its activation induces the release of G(o) and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset,…
Homodimer (PubMed:25112866). Interacts with TRPM3; the interaction results in the formation of a heteromultimeric cation channel complex that are functionally different from the homomeric channels (By similarity). Interacts with GPR179 (PubMed:24114537, PubMed:24790204). Associates with both guanine nucleotide-binding proteins G(o) and beta-gamma G protein dimer; implicated in directly…
Cell membrane, Endoplasmic reticulum membrane, Cell projection, axon, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RMV | X-ray | 1.94 Å | C=610-623 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.