cAMP-dependent protein kinase inhibitor alpha (PKIA) is a 76-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q3SX13.
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The mean pLDDT of this model is 64.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 51% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4C38 | X-ray | 1.58 Å | I=6-25 |
| 5VHB | X-ray | 1.61 Å | B=6-23 |
| 3ZO4 | X-ray | 1.65 Å | I=6-25 |
| 4C33 | X-ray | 1.7 Å | I=6-23 |
| 4C37 | X-ray | 1.7 Å | I=6-25 |
| 8SF8 | X-ray | 1.7 Å | B=6-25 |
| 4C34 | X-ray | 1.78 Å | I=6-23 |
| 5VI9 | X-ray | 1.95 Å | B=6-23 |
| 3ZO2 | X-ray | 1.98 Å | I=6-25 |
| 4C36 | X-ray | 1.98 Å | I=6-25 |
| 3E8E | X-ray | 2.0 Å | C/F/G/J/N/Q=6-25 |
| 3ZO1 | X-ray | 2.0 Å | I=6-23 |
| 4YXR | X-ray | 2.0 Å | I=6-25 |
| 2UZT | X-ray | 2.1 Å | B=6-25 |
| 3ZO3 | X-ray | 2.1 Å | I=6-25 |
| 4C35 | X-ray | 2.19 Å | I=6-23 |
| 2UZW | X-ray | 2.2 Å | I=6-25 |
| 3E8C | X-ray | 2.2 Å | G/H/I/J/K/L=6-25 |
| 2GNJ | X-ray | 2.28 Å | I=6-25 |
| 5VIB | X-ray | 2.37 Å | B=6-23 |
Showing 20 of 22 experimental structures (best resolution first).
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