Programmed cell death protein 4 (PDCD4) is a 469-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q53EL6.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)
Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9TES | X-ray | 1.22 Å | B=67-79 |
| 2RG8 | X-ray | 1.8 Å | A/B=157-320 |
| 9BKD | EM | 2.6 Å | U=1-469 |
| 2ZU6 | X-ray | 2.8 Å | B/E=163-469 |
| 3EIJ | X-ray | 2.8 Å | A/B=157-469 |
| 8XXL | EM | 2.9 Å | CD=1-469 |
| 8XXM | EM | 3.2 Å | CD=1-469 |
| 8XXN | EM | 3.6 Å | CD=1-469 |
| 9BLN | EM | 3.9 Å | p=1-469 |
| 2GGF | NMR | A=327-450 | |
| 2KZT | NMR | A=157-318 |
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