Akirin-2 (AKIRIN2) is a 203-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q53H80.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 65.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 24% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B…
Homodimer (PubMed:34711951). Interacts with IPO9; the interaction is direct (PubMed:34711951). Associates (via SYVS motif) with 20S and 26S proteasomes (PubMed:34711951). Interacts with SMARCD1; promoting SWI/SNF complex recruitment (By similarity). Interacts with NFKBIZ (By similarity). Interacts with YWHAB (By similarity)
Nucleus, Cytoplasm, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7NHT | EM | 2.8 Å | c/d=1-203 |
| 9QON | EM | 3.2 Å | B/C/D=1-203 |
| 9QOO | EM | 3.3 Å | B/C/D/I=1-203 |
| 9QOP | EM | 3.7 Å | B/C=1-203 |
| 9QNO | EM | 4.2 Å | D/E=1-203 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.