9QOP: Akirin-2

Binary complex of human Importin-9 with one homodimer of Akirin-2. Determined by electron microscopy at 3.7 Å resolution. Released 28 Jan 2026.

Method
Electron microscopy
Resolution
3.7 Å
Organism
Homo sapiens
Chains
3
Atoms
4,332
Mol. weight
161.11 kDa
Released
28 Jan 2026

Explore 9QOP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9QOP contains 72 α-helices and 6 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 69 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix17-3317
α-helix37-5115
α-helix56-6510
α-helix71-8818
α-helix103-11210
α-helix113-1164
α-helix123-13715
α-helix146-15712
α-helix160-17314
α-helix182-1898
α-helix205-22521
α-helix234-2374
α-helix241-25111
α-helix254-2563
α-helix262-27514
α-helix280-2845
α-helix287-30519
α-helix306-3105
α-helix329-34214
α-helix350-36415
α-helix365-3684
α-helix369-3713
α-helix372-3787
α-helix382-3876
α-helix398-41215
α-helix418-42811
α-helix432-4376
α-helix444-45613
α-helix458-4658
α-helix474-4774
α-helix478-4825
α-helix483-4864
α-helix492-50413
α-helix506-5083
α-helix511-52212
α-helix5301
α-helix535-55117
α-helix561-57313
α-helix577-59115
α-helix595-6006
α-helix602-61514
α-helix620-63516
α-helix643-65614
α-helix666-68015
α-helix6871
α-helix688-6936
α-helix694-70310
α-helix707-72317
α-helix725-7306
β-strand73212
β-strand73812
α-helix739-75113
α-helix757-7626
α-helix763-7708
α-helix776-7805
α-helix782-79211
α-helix793-7953
α-helix799-81315
α-helix817-82610
α-helix828-8292
α-helix835-8406
α-helix853-86715
α-helix898-9014
α-helix904-9074
α-helix913-93523
α-helix992-9954
α-helix998-10003
α-helix1004-101613
α-helix1022-10254
α-helix1030-10323
α-helix1033-10386
Chain B: 1 helix, 1 β-strand
ElementResiduesLengthSheet
β-strand14211
α-helix144-19148
Chain C: 2 helices, 3 β-strands
ElementResiduesLengthSheet
β-strand7013
β-strand7313
α-helix77-9014
β-strand14211
α-helix144-19148

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Akirin-2B, Cprotein203Homo sapiensQ53H80 (AlphaFold model)
Importin-9Aprotein1041Homo sapiensQ96P70 (AlphaFold model)
Sequence of entity 1 (B, C), FASTA
>9QOP_1 Akirin-2 (chains B, C)
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAAAATAASFSAAAASPQK
YLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLL
SGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYD
AFVKFTHDQIMRRYGEQPASYVS
Sequence of entity 2 (A), FASTA
>9QOP_2 Importin-9 (chains A)
MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHL
AELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRES
ISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDT
QMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTCAHMICNMEELEKGAAKVLIFPV
VQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVTALVKNFPKHMVSSMQQILPIVWNTLTE
SAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFKSTVKKALPEL
IYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAAA
LAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITDSVKNGRIHFDMHGFLTN
VILADLNLSVSPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRA
IWGYCDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTAS
MESKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPAD
KIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAY
VSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGE
NLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVM
AEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSK
SAKNPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEE
EEDGLAGQLLSDILATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPC
YIMFSGHLNDNERRVLQTIGI

Primary citation

A multivalent adaptor mechanism drives the nuclear import of proteasomes. Brunner, H.L., Kalis, R.W., Grundmann, L. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-69162-0 · PubMed

Other PDB entries of the same protein (UniProt Q53H80 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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