R-spondin-2 (rspo2) is a 243-residue protein from Xenopus tropicalis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5M7L6.
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The mean pLDDT of this model is 84.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity). During embryonic development, plays a…
Binds heparin
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4C9R | X-ray | 2.1 Å | B/D=35-144 |
| 4C8V | X-ray | 2.2 Å | A/B/C/D/E/F/G/H=35-144 |
| 4C9A | X-ray | 2.4 Å | B/D=35-144 |
| 4C9V | X-ray | 2.7 Å | B=35-144 |
| 4C9E | X-ray | 3.0 Å | B/D/F/H=35-144 |
| 4C9U | X-ray | 3.0 Å | B/D=35-144 |
| 4C8W | X-ray | 3.1 Å | I/J=35-144 |
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