Ubiquitinating/deubiquitinating enzyme SdeA (sdeA) is a 1499-residue protein from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5ZTK4.
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The mean pLDDT of this model is 86.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Secreted effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several mammalian Rab proteins (Rab33b, Rab1, Rab6a and Rab30) during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2) (PubMed:29795346). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide (PubMed:29795347, PubMed:31330531, PubMed:31330532). The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker that results in the release of AMP (PubMed:27912065). Cannot…
Interacts with IcmS
Secreted, Host cell
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5YSI | X-ray | 1.55 Å | A=756-905 |
| 5CRB | X-ray | 2.0 Å | A/B=1-193 |
| 5YSJ | X-ray | 2.06 Å | A/B/C/D=756-905 |
| 6B7Q | X-ray | 2.2 Å | A=206-910 |
| 5YSK | X-ray | 2.4 Å | A/B/C/D=756-905 |
| 7MIR | EM | 2.5 Å | C=231-1190 |
| 6WTG | X-ray | 2.63 Å | A=1-193 |
| 5CRA | X-ray | 2.64 Å | A/B=1-193 |
| 6G0C | X-ray | 2.8 Å | A=213-907 |
| 8EFW | X-ray | 2.81 Å | B=1-196 |
| 5CRC | X-ray | 2.85 Å | A/B=1-193 |
| 7PPO | EM | 2.91 Å | A=231-1190 |
| 7PQE | EM | 3.7 Å | A=231-1190 |
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