Non-selective voltage-gated ion channel VDAC1 (Vdac1) is a 296-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q60932.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and…
Homodimer and homotrimer; in response to cyclic AMP or calcium; oligomerization is required for scramblase activity (By similarity). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF. Interacts with SPG7, NIPSNAP2 and SLC25A30 (By similarity). Interacts with hexokinases including HK1. The HK1-VDAC1 complex interacts with ATF2.…
Mitochondrion outer membrane, Cell membrane, Membrane raft
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4C69 | X-ray | 2.28 Å | X=14-296 |
| 3EMN | X-ray | 2.3 Å | X=14-296 |
| 9GNG | X-ray | 2.4 Å | X=14-296 |
| 7TCV | X-ray | 2.6 Å | XXX=14-296 |
| 7KUH | EM | 3.12 Å | X=14-296 |
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