Lymphocyte activation gene 3 protein (Lag3) is a 521-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q61790.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Inhibitory receptor on antigen activated T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887, PubMed:30580966, PubMed:35413245, PubMed:35761082, PubMed:38483996, PubMed:39209860). Delivers inhibitory signals upon binding to ligands, such as MHC class II, its main ligand present at the surface of antigen-presenting cells (APCs), and FGL1, which is secreted by hepatocytes and certain types of tumor cells (PubMed:12209638, PubMed:12421911, PubMed:30349037, PubMed:30580966, PubMed:35413245, PubMed:35761082, PubMed:39209860). Ligand-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell…
Homodimer (PubMed:35761082, PubMed:38483996, PubMed:39209860). Interacts with CD3E; disrupting the association between CD3E and LCK, thereby preventing TCR activation (PubMed:40592325)
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7TZE | X-ray | 2.12 Å | A/C=23-254 |
| 8DGG | X-ray | 3.78 Å | A/B=23-442 |
| 9CYM | X-ray | 3.84 Å | L=23-255 |
| 9CYL | X-ray | 4.66 Å | L=23-254 |
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