Protein-glutamine deamidase Cif (cif) is a 328-residue protein from Burkholderia pseudomallei (strain K96243). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q63KH5.
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The mean pLDDT of this model is 82.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Protein-glutamine deamidase effector that inhibits the host cell cycle and other key cellular processes such as the actin network and programmed-cell death (PubMed:19225106, PubMed:19308257, PubMed:20688984). Acts by mediating the side chain deamidation of 'Gln-40' of host NEDD8, converting it to glutamate, thereby abolishing the activity of cullin-RING-based E3 ubiquitin-protein ligase complexes (CRL complexes) (PubMed:20688984, PubMed:21903097). Inactivation of CRL complexes prevents ubiquitination and subsequent degradation of the cyclin-dependent kinase inhibitors CDKN1A/p21 and CDKN1B/p27, leading to G1 and G2 cell cycle arrests in host cells (PubMed:19308257). Deamidation of 'Gln-40'…
Secreted, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3EIR | X-ray | 2.1 Å | A/B=48-328 |
| 3GQM | X-ray | 2.1 Å | A/B=67-328 |
| 4HCP | X-ray | 2.52 Å | A=78-328 |
| 3EIT | X-ray | 2.56 Å | A/B=48-328 |
| 4HCN | X-ray | 2.6 Å | A=78-328 |
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