X-ray repair cross-complementing protein 5 (xrcc5.L) is a 726-residue protein from Xenopus laevis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6DDS9.
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The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
DNA-binding protein critical for the DNA damage response, specifically in repairing double-strand breaks (DSBs) via the classical non-homologous end joining (NHEJ) pathway. It forms a heterodimer with xrcc6/Ku70, creating the Ku70:Ku80 heterodimer (Ku complex), which serves as a DNA end-binding complex. It primarily binds DSBs and recruits essential repair factors, assembling the core long-range NHEJ complex to facilitate the alignment and ligation of broken DNA ends
Heterodimer composed of xrcc5/Ku80 and xrcc6/Ku70
Nucleus, Nucleus, nucleolus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TYU | X-ray | 1.47 Å | A=1-242 |
| 6TYZ | X-ray | 1.51 Å | A=1-242 |
| 6TYW | X-ray | 1.7 Å | A=1-242 |
| 6TYX | X-ray | 1.9 Å | A/B=1-242 |
| 6TYV | X-ray | 1.93 Å | A=1-242 |
| 6TYT | X-ray | 2.4 Å | A=1-242 |
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