IGH@ protein (IGH@) is a 465-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: Q6GMX6.
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The mean pLDDT of this model is 88.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5VSI | X-ray | 1.51 Å | H=20-235 |
| 6DC4 | X-ray | 1.7 Å | H=20-239 |
| 4NPY | X-ray | 1.8 Å | A/L=31-238, B/H=20-116, B/H=119-238 |
| 6BAH | X-ray | 1.9 Å | B=20-116, B=119-238 |
| 4LKX | X-ray | 1.92 Å | A=20-243 |
| 3ZL4 | X-ray | 1.95 Å | H=20-238 |
| 6B9Y | X-ray | 2.14 Å | B=20-116, B=119-238 |
| 5VR9 | X-ray | 2.15 Å | A/H=20-238 |
| 6VPY | X-ray | 2.36 Å | A/H=20-240 |
| 4FQQ | X-ray | 2.42 Å | B/D/F/H=20-116, B/D/F/H=119-242 |
| 6AL4 | X-ray | 2.45 Å | B/D/F=20-238 |
| 4D9L | X-ray | 2.48 Å | H/I/J/K=20-237 |
| 5UTZ | X-ray | 2.75 Å | B/F/H/J=20-238 |
| 8BBO | X-ray | 2.75 Å | H=20-48, H=52-240 |
| 1ZA6 | X-ray | 2.8 Å | B/D/F/H=20-465 |
| 7CZX | EM | 2.8 Å | H/I/J=117-465 |
| 5O1R | X-ray | 2.86 Å | H/I=20-240 |
| 4QHN | X-ray | 3.0 Å | A=20-242 |
| 7D00 | EM | 3.0 Å | H/J=122-465 |
| 4QHL | X-ray | 3.15 Å | A/C=20-242 |
Showing 20 of 28 experimental structures (best resolution first).
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