Nuclear factor related to kappa-B-binding protein (NFRKB) is a 1299-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6P4R8.
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The mean pLDDT of this model is 54.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3U21 | X-ray | 2.18 Å | A/B=370-495 |
| 4WLP | X-ray | 3.1 Å | B=40-153 |
| 4UF6 | X-ray | 3.69 Å | C/F/I/L=40-101 |
| 4UF5 | X-ray | 3.7 Å | B=40-170 |
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