Leiomodin-2 (LMOD2) is a 547-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6P5Q4.
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The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713)
Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation (PubMed:18403713, PubMed:26417072). Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus) (PubMed:25250574, PubMed:26873245). May also interact with TPM2 (via N-terminus) (PubMed:25250574). Interacts with FLII (By similarity)
Cytoplasm, myofibril, sarcomere, Cytoplasm, myofibril, Cytoplasm, myofibril, sarcomere, M line, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4RWT | X-ray | 2.98 Å | C/D=1-547 |
| 5WFN | X-ray | 3.0 Å | C/D=1-547 |
| 6UT2 | NMR | A=2-41 |
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