ATPase family AAA domain-containing protein 2 (ATAD2) is a 1390-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6PL18.
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The mean pLDDT of this model is 61.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells
Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5R4V | X-ray | 1.29 Å | A=981-1108 |
| 7Z9H | X-ray | 1.34 Å | AAA=981-1108 |
| 7Z9N | X-ray | 1.34 Å | AAA=981-1108 |
| 7PPX | X-ray | 1.35 Å | AAA=981-1108 |
| 8RU5 | X-ray | 1.36 Å | A=981-1108 |
| 5R4X | X-ray | 1.4 Å | A=981-1108 |
| 5QXN | X-ray | 1.41 Å | A=981-1108 |
| 5QXP | X-ray | 1.41 Å | A=981-1108 |
| 7QYK | X-ray | 1.43 Å | AAA=981-1108 |
| 7R0Y | X-ray | 1.43 Å | AAA=981-1108 |
| 5R4F | X-ray | 1.44 Å | A=981-1108 |
| 7QYL | X-ray | 1.44 Å | AAA=981-1108 |
| 7QZM | X-ray | 1.45 Å | AAA=981-1108 |
| 5QXJ | X-ray | 1.46 Å | A=981-1108 |
| 5R4Z | X-ray | 1.46 Å | A=981-1108 |
| 5QXO | X-ray | 1.47 Å | A=981-1108 |
| 5R4W | X-ray | 1.47 Å | A=981-1108 |
| 7QUK | X-ray | 1.47 Å | AAA=981-1108 |
| 7Z9O | X-ray | 1.47 Å | AAA=981-1108 |
| 7R00 | X-ray | 1.48 Å | AAA=981-1108 |
Showing 20 of 120 experimental structures (best resolution first).
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