RNA-directed RNA polymerase L (L) is a 734-residue protein from Crimean-Congo hemorrhagic fever virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q6TQR6.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 69.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 31% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities (PubMed:18078692, PubMed:21228232, PubMed:21245344, PubMed:23345508). RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome (PubMed:18078692). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs (By similarity). These short capped RNAs are then used as primers for viral transcription (By similarity). The deubiquitinating and deISGylating activities specifically cleaves poly-ubiquitinated conjugates and ISG15 from RIG-I, interfering…
Interacts (via N-terminus) with host ISG15 (via C-terminus); the deISGylase activity of the viral protein interferes with antiviral signaling pathways mediated by NF-kappaB and IRF signalings (PubMed:21245344, PubMed:21266548). Interacts with host ubiquitin (PubMed:21245344)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5V5H | X-ray | 1.5 Å | A=1-169 |
| 3PHX | X-ray | 1.6 Å | A=1-183 |
| 3PRP | X-ray | 1.7 Å | A/C=1-170 |
| 3PHW | X-ray | 2.0 Å | A/C/E/G=1-183 |
| 5V5G | X-ray | 2.1 Å | A/C=1-183 |
| 3PHU | X-ray | 2.2 Å | A/B=1-217 |
| 5V5I | X-ray | 2.2 Å | A/C=1-169 |
| 3PRM | X-ray | 2.3 Å | A/C=1-170 |
| 3PSE | X-ray | 2.3 Å | A=1-169 |
| 3ZNH | X-ray | 2.3 Å | A=1-183 |
| 3PT2 | X-ray | 2.5 Å | A=1-184 |
| 9YBN | EM | 2.53 Å | A=1-3945 |
| 9YBM | EM | 2.62 Å | A=1-3945 |
| 9XD5 | EM | 2.72 Å | A=1-3945 |
| 9XD6 | EM | 2.74 Å | A=1-3945 |
| 9XD4 | EM | 2.79 Å | A=1-3945 |
| 9XE9 | EM | 2.81 Å | A=1-3945 |
| 9XEC | EM | 2.98 Å | A=1-3945 |
| 9XE7 | EM | 3.02 Å | A=1-3945 |
| 9XE6 | EM | 3.09 Å | A=1-3945 |
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