Interleukin-27 receptor subunit alpha (IL27RA) is a 636-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6UWB1.
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The mean pLDDT of this model is 78.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Signal-transducing subunit for an heterodimeric cytokine composed of IL27/p28 and a soluble receptor EBI3 (PubMed:14764690, PubMed:36930708). Heterodimerizes with IL6ST/GP130 to mediate signal transduction in response to the heterodimeric cytokine IL27/p28-EBI3. This signaling system acts through STAT3 and STAT1 (PubMed:14764690, PubMed:38509369). Also acts as a signaling receptor as part of the humanin receptor complex; binding of MT-RNR2/humanin (HN) activates the intracellular JAK-STAT3 signaling pathway leading to neuroprotection (PubMed:19386761). Involved in the regulation of Th1-type immune responses (By similarity). Also appears to be involved in innate defense mechanisms…
Component of the humanin (HN) receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR; MT-RNR2, the neuroprotective peptide HN, binds to CNTFR and IL27RA (PubMed:19386761). Component of the interleukin-27 signaling complex composed of IL27, EBI3, IL6ST/GP130 and IL27RA/WSX1; a heterodimeric cytokine, composed of IL27/p28 and a soluble receptor EBI3, that signals via IL27RA/WSX1 and…
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7T5M | X-ray | 1.67 Å | E/F=617-636 |
| 7U7N | EM | 3.47 Å | A=36-231 |
| 8D85 | EM | 3.81 Å | A=33-516 |
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