E3 ubiquitin-protein ligase ARK2C (ARK2C) is a 346-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6ZSG1.
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The mean pLDDT of this model is 57.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 55% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL
Monomer; binding to the ubiquitin-conjugating enzyme E2 does not trigger homodimerization (PubMed:26656854)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5D0I | X-ray | 1.9 Å | A/B=255-346 |
| 5D0M | X-ray | 1.91 Å | C=255-346 |
| 5ULH | X-ray | 1.95 Å | C=255-346 |
| 9N1F | X-ray | 2.1 Å | A=255-346 |
| 5ULK | X-ray | 2.38 Å | C=255-346 |
| 7R70 | X-ray | 2.5 Å | A/B=255-346 |
| 5D0K | X-ray | 2.65 Å | C/F/I/L=255-346 |
| 7R71 | X-ray | 2.8 Å | A=255-346 |
| 9QAL | NMR | A=279-346 |
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