Ubiquitin carboxyl-terminal hydrolase 30 (USP30) is a 517-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q70CQ3.
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The mean pLDDT of this model is 76.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of…
Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9F6G | X-ray | 1.5 Å | A=64-178, A=190-224, A=249-275, A=319-349, A=437-502 |
| 5OHK | X-ray | 2.34 Å | A=64-178, A=190-357, A=432-502 |
| 9LYF | X-ray | 2.58 Å | A=64-178, A=190-357, A=432-502 |
| 9F19 | X-ray | 2.75 Å | A/B=64-178, A/B=190-224, A/B=253-275, A/B=319-349, A/B=437-502 |
| 5OHP | X-ray | 2.8 Å | A=64-178, A=190-357, A=432-502 |
| 8D1T | X-ray | 2.94 Å | A=64-178, A=190-357, A=432-502 |
| 8D0A | X-ray | 3.19 Å | A=64-178, A=190-357, A=432-502 |
| 5OHN | X-ray | 3.6 Å | A/C=64-357, A/C=432-502 |
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