Sodium-dependent dopamine transporter (DAT) is a 631-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q7K4Y6.
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The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:11125028, PubMed:12606774, PubMed:24037379, PubMed:25970245). Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin (PubMed:11125028, PubMed:12606774). Plays a role in the regulation of the rest/activity cycle (PubMed:16093388, PubMed:25232310)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7WGT | X-ray | 2.75 Å | A=25-601 |
| 4XP4 | X-ray | 2.8 Å | A=21-601 |
| 4XP9 | X-ray | 2.8 Å | C=25-601 |
| 6M2R | X-ray | 2.8 Å | A=25-601 |
| 6M0Z | X-ray | 2.88 Å | A=25-601 |
| 4XP1 | X-ray | 2.89 Å | A=25-600 |
| 4XPH | X-ray | 2.9 Å | A=25-599 |
| 7WLW | X-ray | 2.9 Å | A=25-601 |
| 4XPA | X-ray | 2.95 Å | A=21-601 |
| 4M48 | X-ray | 2.96 Å | A=21-601 |
| 4XNU | X-ray | 2.98 Å | A=25-599 |
| 4XNX | X-ray | 3.0 Å | A=25-601 |
| 6M38 | X-ray | 3.0 Å | A=25-599 |
| 9EUP | EM | 3.0 Å | A=21-601 |
| 4XPB | X-ray | 3.05 Å | A=21-601 |
| 4XP6 | X-ray | 3.1 Å | A=25-599 |
| 6M3Z | X-ray | 3.11 Å | A=25-601 |
| 7WGD | X-ray | 3.2 Å | A=25-601 |
| 9EUO | EM | 3.2 Å | A=21-601 |
| 4XPG | X-ray | 3.21 Å | A=21-601 |
Showing 20 of 25 experimental structures (best resolution first).
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