Staphylococcal nuclease domain-containing protein 1 (SND1) is a 910-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q7KZF4.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity)
Forms a ternary complex with STAT6 and POLR2A (PubMed:12234934). Associates with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:28546213). Interacts with the RISC components AGO2, FMR1 and TNRC6A (PubMed:14508492, PubMed:28546213). Interacts with GTF2E1 and GTF2E2 (PubMed:7651391). Interacts with PIM1 (PubMed:9809063). Interacts with STAT5 (By similarity). Interacts with SYT11…
Cytoplasm, Nucleus, Melanosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2HQX | X-ray | 1.42 Å | A/B=665-910 |
| 5M9O | X-ray | 1.45 Å | A=677-900 |
| 3OMC | X-ray | 1.77 Å | A/B=650-910 |
| 3OMG | X-ray | 1.85 Å | A/B=650-910 |
| 3BDL | X-ray | 1.9 Å | A=340-888 |
| 2HQE | X-ray | 2.0 Å | A/B=665-910 |
| 2O4X | X-ray | 2.0 Å | A=679-895, B=705-795 |
| 7KNW | X-ray | 2.65 Å | A/B/C/D=16-330 |
| 4QMG | X-ray | 2.7 Å | A/B/C/D/E=16-339 |
| 7KNX | X-ray | 2.7 Å | A/B/C/D=16-330 |
| 2E6N | NMR | A=703-800 |
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