Synaptic vesicle glycoprotein 2A (SV2A) is a 742-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q7L0J3.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity)
Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity)
Presynapse, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4V11 | X-ray | 1.95 Å | B=81-90 |
| 9OKH | EM | 2.39 Å | A=139-742 |
| 9OKG | EM | 2.58 Å | A=139-742 |
| 9OKI | EM | 2.67 Å | A=139-742 |
| 9OKJ | EM | 2.68 Å | A=139-742 |
| 9OKF | EM | 2.8 Å | A=139-742 |
| 8JLE | EM | 2.82 Å | A=480-587 |
| 8JLG | EM | 2.87 Å | A=480-590 |
| 8JLC | EM | 2.88 Å | A=2-742 |
| 8JS8 | EM | 2.88 Å | A=2-742 |
| 8JLH | EM | 2.9 Å | A/C=2-742 |
| 9PC9 | EM | 2.91 Å | A=1-742 |
| 8JLF | EM | 3.01 Å | A=2-742 |
| 8JS9 | EM | 3.01 Å | A=2-742 |
| 9PRS | EM | 3.03 Å | A=139-742 |
| 9NTC | EM | 3.05 Å | A=64-742 |
| 8K77 | EM | 3.11 Å | A=2-742 |
| 8UO9 | EM | 3.3 Å | A=64-742 |
| 8JLI | EM | 3.38 Å | A/B=2-742 |
| 8YF1 | EM | 3.38 Å | A/B=1-734 |
Showing 20 of 23 experimental structures (best resolution first).
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