Tubulinyl-Tyr carboxypeptidase 1 (VASH1) is a 365-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q7L8A9.
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The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31171830, PubMed:31235910, PubMed:31235911, PubMed:31270470). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the…
Interacts with SVBP; interaction enhances VASH1 tyrosine carboxypeptidase activity
Cytoplasm, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6J7B | X-ray | 1.62 Å | A=57-306 |
| 6OCG | X-ray | 1.83 Å | A=59-305 |
| 6J8O | X-ray | 1.85 Å | B=69-306 |
| 6J8N | X-ray | 1.95 Å | B/D=69-306 |
| 6J4U | X-ray | 2.0 Å | A=57-307 |
| 6OCH | X-ray | 2.0 Å | A/C=61-302 |
| 6NVQ | X-ray | 2.1 Å | C=1-315 |
| 6OCF | X-ray | 2.1 Å | A=58-305 |
| 6J8F | X-ray | 2.28 Å | B=69-306 |
| 6K81 | X-ray | 2.28 Å | A=1-365 |
| 6LPG | X-ray | 2.3 Å | A=56-310 |
| 6J9H | X-ray | 2.31 Å | B/D=69-306 |
| 6WSL | EM | 3.1 Å | C/G=52-310 |
| 6J91 | X-ray | 3.5 Å | B=69-306 |
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