Autophagy-related protein 9A (ATG9A) is a 839-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q7Z3C6.
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The mean pLDDT of this model is 73.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving…
Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets (PubMed:32610138, PubMed:33106659). Interacts (via cytoplasmic its C-terminus) with ATG2A (PubMed:32610138, PubMed:33106659). Interacts with SUPT20H (PubMed:19893488). Interacts (via the tyrosine-based sorting signal motif) with AP4M1; promoting association with the AP-4 complex…
Preautophagosomal structure membrane, Cytoplasmic vesicle, autophagosome membrane, Golgi apparatus, trans-Golgi network membrane, Late endosome membrane, Recycling endosome membrane, Endoplasmic reticulum membrane, Mitochondrion membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6WQZ | EM | 2.8 Å | A/B/C/D/E/F=1-688 |
| 6WR4 | EM | 2.9 Å | A/B/C=1-839 |
| 7JLO | EM | 3.4 Å | A/B/C=1-578 |
| 7JLP | EM | 3.4 Å | A/B/C=1-578 |
| 8KBZ | EM | 3.97 Å | A/B/C=1-839 |
| 7JLQ | EM | 4.0 Å | A/B/C=1-578 |
| 8KC3 | EM | 7.0 Å | A/B/C=1-839 |
| 8Y1L | EM | 7.05 Å | C/D/E=1-839 |
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