Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery. Determined by electron microscopy at 2.9 Å resolution. Released 8 Jul 2020.
Explore 6WR4 in 3D Show helices and sheets RCSB PDB PDBe
6WR4 contains 81 α-helices and 24 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 43-55 | 13 | |
| α-helix | 59-85 | 27 | |
| β-strand | 87 | 1 | 1 |
| α-helix | 89-93 | 5 | |
| α-helix | 112-114 | 3 | |
| β-strand | 116 | 1 | 1 |
| α-helix | 117-118 | 2 | |
| α-helix | 119-122 | 4 | |
| α-helix | 130-166 | 37 | |
| α-helix | 180-189 | 10 | |
| α-helix | 209-212 | 4 | |
| α-helix | 216-224 | 9 | |
| β-strand | 231-234 | 4 | 2 |
| β-strand | 238-241 | 4 | 2 |
| α-helix | 245-255 | 11 | |
| α-helix | 272-274 | 3 | |
| α-helix | 280-299 | 20 | |
| α-helix | 301-322 | 22 | |
| β-strand | 330 | 1 | 3 |
| α-helix | 334-339 | 6 | |
| α-helix | 347-354 | 8 | |
| α-helix | 358-364 | 7 | |
| α-helix | 366-368 | 3 | |
| α-helix | 371-398 | 28 | |
| α-helix | 407-424 | 18 | |
| α-helix | 438-444 | 7 | |
| α-helix | 465-468 | 4 | |
| β-strand | 471 | 1 | 3 |
| α-helix | 472-480 | 9 | |
| α-helix | 482-489 | 8 | |
| α-helix | 490-494 | 5 | |
| α-helix | 495-497 | 3 | |
| α-helix | 498-507 | 10 | |
| β-strand | 510-512 | 3 | 4 |
| β-strand | 516-518 | 3 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Autophagy-related protein 9A | A, B, C | protein | 839 | Homo sapiens | Q7Z3C6 (AlphaFold model) |
>6WR4_1 Autophagy-related protein 9A (chains A, B, C) MAQFDTEYQRLEASYSDSPPGEEDLLVHVAEGSKSPWHHIENLDLFFSRVYNLHQKNGFT CMLIGEIFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQ VCSARIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTW QEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEA VFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLL CPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKP ASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTV CRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEEL LSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSAGQT EASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAASLAQGGLLP ENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLQP GQAPTGRAHSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQ AQAEPERHVWHRRESDESGESAPDEGGEGARAPQSIPRSASYPCAAPRPGAPETTALHGG FQRRYGGITDPGTVPRVPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV
| ID | Name | Formula | Copies |
|---|---|---|---|
| LMN | Lauryl Maltose Neopentyl Glycol | C47 H88 O22 | 6 |
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Guardia, C.M., Tan, X.F., Lian, T. et al. Cell Rep (2020) 31:107837-107837. DOI 10.1016/j.celrep.2020.107837 · PubMed
Other PDB entries of the same protein (UniProt Q7Z3C6 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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