Serine/threonine-protein kinase tousled-like 2 (TLK2) is a 772-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86UE8.
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The mean pLDDT of this model is 71.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037)
Monomer (PubMed:29955062). May form homodimers; homodimerization may enhance autophosphoylation and enzymatic activity (PubMed:29955062). Heterodimer with TLK1 (PubMed:10523312, PubMed:29955062, PubMed:33323470). Interacts with YWHAZ; association with 14-3-3 proteins such as YWHAZ regulates subcellular location (PubMed:10455159). May also interact with FEZ1/LZTS1 and FEZ2 (PubMed:16484223).…
Nucleus, Nucleus, nucleoplasm, Cytoplasm, perinuclear region, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7LO0 | X-ray | 2.71 Å | I/J/K/L/M/N/O/P/Q/R/T/U/V/W/X/Y=3-23 |
| 5O0Y | X-ray | 2.86 Å | A=191-755 |
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