Calcium-activated potassium channel subunit beta-4 (KCNMB4) is a 210-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86W47.
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The mean pLDDT of this model is 87.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations
Interacts with KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). Interacts with FMR1 (via N-terminus) (PubMed:25561520)
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9CZM | EM | 2.57 Å | E/F/G/H=16-210 |
| 9CZO | EM | 2.87 Å | E/F/G/H=16-210 |
| 9CZQ | EM | 2.88 Å | E/F/G/H=16-210 |
| 9D18 | EM | 2.88 Å | E/F/G/H=16-210 |
| 9D19 | EM | 2.88 Å | E/F/G/H=16-210 |
| 9CZH | EM | 2.9 Å | E/F/G/H=16-210 |
| 6V22 | EM | 3.2 Å | E/F/G/H=1-210 |
| 6V35 | EM | 3.5 Å | E/F/G/H=1-210 |
| 9CZK | EM | 3.5 Å | E/F/G/H=16-210 |
| 9CZJ | EM | 3.54 Å | E/F/G/H=16-210 |
| 5Y7L | NMR | A=45-166 |
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