Sorting nexin-32 (SNX32) is a 403-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86XE0.
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The mean pLDDT of this model is 88.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Involved in endosomal trafficking of cargo proteins, including transferrin-bound transferrin receptor (TFRC), cation-independent mannose-6-phosphate receptor (IGF2R) and epidermal growth factor receptor (EGFR) (PubMed:37158588, PubMed:39073202). Functions redundantly with other BAR domain-containing sorting nexins in endosome to trans-Golgi network transport of IGF2R (PubMed:39073202). Regulates in coordination with SNX5 sorting and trafficking of EGF-activated EGFR to multivesicular bodies for lysosomal degradation (PubMed:39073202). Plays an essential role in neurite outgrowth, controlling basigin/EMMPRIN (BSG) trafficking to the cell surface (By similarity)
Interacts with BAR domain-containing sorting nexins SNX1, SNX2, SNX4, SNX5 and SNX6 (PubMed:37158588, PubMed:39073202). Interacts (via PX domain) with cargo proteins transferrin-bound TFRC, IGF2R and BSG; the interaction regulates their intracellular trafficking (PubMed:37158588). Interacts with EGFR; the interaction is required for endolysosomal EGFR trafficking (PubMed:39073202)
Cell membrane, Early endosome, Golgi apparatus, trans-Golgi network, Recycling endosome, Late endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6E8R | X-ray | 2.27 Å | A/B=17-166 |
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