MyoD family inhibitor domain-containing protein (Mdfic) is a 247-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8BX65.
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The mean pLDDT of this model is 53.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 43% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (PubMed:15207726, PubMed:15465018). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (By similarity). Affects axin-regulation of the WNT and JNK signaling pathways (By similarity). Involved in the development of lymphatic vessel valves (PubMed:35235341). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation…
Interacts with HAND1; the interaction sequesters Hand1 into the nucleolus and inhibits its activity (PubMed:17891141). Interacts (via C-terminus) with ZIC2 (PubMed:15207726, PubMed:15465018). Interacts (via C-terminus) with AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1 (By similarity). Interacts with CCNT2 (By similarity). Interacts with GATA2 (PubMed:35235341).…
Cytoplasm, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8IMZ | EM | 3.66 Å | D/E/F=1-247 |
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