Neuroligin-3 (Nlgn3) is a 825-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8BYM5.
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The mean pLDDT of this model is 77.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system
Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity). Interacts with neurexins NRXN1, NRXN2 and NRXN3 (By similarity). Interaction with neurexins is mediated by heparan sulfate glycan modification on neurexin (PubMed:30100184). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity)
Cell membrane, Synapse, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
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