7CEE: Mouse neuroligin-3

Crystal structure of mouse neuroligin-3. Determined by X-ray diffraction at 2.76 Å resolution. Released 24 Feb 2021.

Method
X-ray diffraction
Resolution
2.76 Å
Organism
Mus musculus
Chains
2
Atoms
8,489
Mol. weight
146.87 kDa
Ligands
NAG
Released
24 Feb 2021

Explore 7CEE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7CEE contains 64 α-helices and 28 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 31 helices, 14 β-strands

ElementResiduesLengthSheet
β-strand40-4341
β-strand46-4941
β-strand51-5332
α-helix61-622
β-strand63-7082
α-helix77-793
α-helix86-894
β-strand93-9531
α-helix99-1035
α-helix118-1214
α-helix124-1318
β-strand140-14672
β-strand177-18372
α-helix193-1953
α-helix199-2057
β-strand208-21252
α-helix217-2215
α-helix233-24816
α-helix249-2524
β-strand254-264112
α-helix266-27510
β-strand286-29052
α-helix304-31411
α-helix322-33110
α-helix334-3396
α-helix364-3707
α-helix372-3754
β-strand377-38372
α-helix388-3903
α-helix392-3943
α-helix403-41816
α-helix424-43411
α-helix444-45613
α-helix457-4615
α-helix462-47110
β-strand478-48362
α-helix504-5074
α-helix510-5123
α-helix525-54420
α-helix571-5733
β-strand579-58352
β-strand588-59142
α-helix595-5995
α-helix600-6045
α-helix605-6084
Chain B: 33 helices, 14 β-strands
ElementResiduesLengthSheet
β-strand40-4343
β-strand46-4943
β-strand51-5334
α-helix61-622
β-strand63-7084
α-helix77-793
α-helix86-894
α-helix931
β-strand94-9523
α-helix101-1033
α-helix118-1214
α-helix124-1318
β-strand140-14674
α-helix1761
β-strand177-18374
α-helix193-1953
α-helix199-2057
β-strand208-21254
α-helix217-2215
α-helix233-24816
α-helix249-2524
β-strand254-264114
α-helix266-27510
β-strand286-29054
α-helix304-31411
α-helix322-33110
α-helix334-3396
α-helix364-3707
α-helix372-3754
β-strand377-38374
α-helix388-3914
α-helix392-3943
α-helix403-41816
α-helix424-43411
α-helix444-45613
α-helix457-4615
α-helix462-47110
β-strand478-48364
α-helix504-5074
α-helix510-5123
α-helix525-54420
α-helix571-5733
β-strand579-58354
β-strand588-59144
α-helix595-5995
α-helix600-6045
α-helix605-6084

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Neuroligin-3A, Bprotein655Mus musculusQ8BYM5 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>7CEE_1 Neuroligin-3 (chains A, B)
APAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRN
ATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKK
QGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYR
VGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLT
LSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAK
ELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVV
DPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALF
TDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGP
TDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNP
RDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHI
TRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTEHHHHHH

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O64

Primary citation

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice. Yoshida, T., Yamagata, A., Imai, A. et al. Nat Commun (2021) 12:1848-1848. DOI 10.1038/s41467-021-22059-6 · PubMed

Other PDB entries of the same protein (UniProt Q8BYM5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 7CEE directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.