E3 ubiquitin-protein ligase SIAH1 (SIAH1) is a 282-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IUQ4.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:28546513, PubMed:32430360, PubMed:33591310, PubMed:9334332, PubMed:9858595, PubMed:41062835). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595).…
Homodimer. Interacts with group 1 glutamate receptors GRM1 and GRM5. Interacts with DAB1, which may inhibit its activity. Interacts with UBE2E2. Interacts with PEG3. Interacts with GAPDH; leading to stabilize SIAH1 (By similarity). Component of some large E3 complex composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with UBE2I. Interacts with alpha-tubulin. Interacts with…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CA1 | X-ray | 1.58 Å | A/B=91-282 |
| 9G0L | X-ray | 1.9 Å | A=28-125 |
| 4C9Z | X-ray | 1.95 Å | A/B=91-282 |
| 5WZZ | X-ray | 2.1 Å | A/B/C/D=93-282 |
| 2A25 | X-ray | 2.2 Å | A=90-282 |
| 4X3G | X-ray | 2.34 Å | A/B=91-282 |
| 4I7D | X-ray | 2.4 Å | A/C=90-282 |
| 8HEO | X-ray | 2.53 Å | A/B=89-282 |
| 4I7C | X-ray | 2.8 Å | A/C=90-282 |
| 4I7B | X-ray | 3.0 Å | A/C=90-282 |
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