NAD-dependent protein deacetylase sirtuin-2 (SIRT2) is a 389-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IXJ6.
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The mean pLDDT of this model is 81.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy (PubMed:12620231,…
Interacts with CDC20, FOXO3 and FZR1. Associates with microtubules in primary cortical mature neurons (By similarity). Homotrimer. Isoform 1 and isoform 2 interact (via both phosphorylated, unphosphorylated, active or inactive forms) with HDAC6; the interaction is necessary for the complex to interact with alpha-tubulin, suggesting that these proteins belong to a large complex that deacetylates…
Nucleus, Cytoplasm, perinuclear region, Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytoskeleton, spindle, Midbody, Chromosome, Perikaryon, Cell…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9S1Z | X-ray | 1.1 Å | A=56-356 |
| 9FDR | X-ray | 1.25 Å | A=56-356 |
| 9FDS | X-ray | 1.4 Å | A=56-356 |
| 4RMH | X-ray | 1.42 Å | A=56-356 |
| 4RMI | X-ray | 1.45 Å | A=56-356 |
| 9S46 | X-ray | 1.45 Å | A=56-356 |
| 9S48 | X-ray | 1.45 Å | A=56-356 |
| 5YQO | X-ray | 1.48 Å | A=56-356 |
| 4X3O | X-ray | 1.5 Å | A=52-355 |
| 9S20 | X-ray | 1.5 Å | A=56-356 |
| 8QOO | X-ray | 1.55 Å | A=56-356 |
| 8QT1 | X-ray | 1.55 Å | A=56-356 |
| 8QT3 | X-ray | 1.55 Å | A=56-356 |
| 8QT4 | X-ray | 1.55 Å | A=56-356 |
| 9FDU | X-ray | 1.55 Å | A=56-356 |
| 9FDX | X-ray | 1.55 Å | A=56-356 |
| 9S21 | X-ray | 1.55 Å | A=56-356 |
| 4Y6L | X-ray | 1.6 Å | A/B=52-356 |
| 4Y6O | X-ray | 1.6 Å | A/B=52-356 |
| 5YQL | X-ray | 1.6 Å | A=56-356 |
Showing 20 of 77 experimental structures (best resolution first).
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