Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) is a 650-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8NHL6.
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The mean pLDDT of this model is 73.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes…
Binds PTPN6 when phosphorylated (PubMed:9285411). Binds FCER1A and FCGR1A (PubMed:11907092, PubMed:9842885). Interacts with human cytomegalovirus/HHV-5 protein UL18 (PubMed:10591185). Interacts with peptide-bound HLA-G-B2M complex (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M complex but not with peptide-free HLA-F open conformer. It does not probe the peptide sequence directly…
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1UGN | X-ray | 1.8 Å | A=24-221 |
| 1G0X | X-ray | 2.1 Å | A=25-221 |
| 3D2U | X-ray | 2.21 Å | D/H=24-221 |
| 6EWO | X-ray | 2.3 Å | D/H=27-221 |
| 6EWA | X-ray | 2.39 Å | D/H=27-221 |
| 7KFK | X-ray | 2.63 Å | A/B=222-421 |
| 4LL9 | X-ray | 2.69 Å | A/B/C=222-417 |
| 4NO0 | X-ray | 2.7 Å | D=27-221 |
| 1VDG | X-ray | 2.8 Å | A/B=24-220 |
| 1UFU | X-ray | 3.0 Å | A=25-221 |
| 6ZDX | X-ray | 3.0 Å | B=25-420 |
| 6K60 | X-ray | 3.15 Å | D/H=24-220 |
| 6EWC | X-ray | 3.2 Å | D/H=27-221 |
| 5KNM | X-ray | 3.3 Å | D=24-221 |
| 6AEE | X-ray | 3.3 Å | G/H=25-417 |
| 1P7Q | X-ray | 3.4 Å | D=25-221 |
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