Q8R3R8: Gamma-aminobutyric acid receptor-associated protein-like 1 (Gabarapl1)

Gamma-aminobutyric acid receptor-associated protein-like 1 (Gabarapl1) is a 117-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8R3R8.

Gene
Gabarapl1
Organism
Mus musculus
Length
117 residues
Mean pLDDT
95.3
Model
AF-Q8R3R8-F1 v6
Model created
1 Aug 2025
PDB structures
2

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Model confidence (pLDDT)

The mean pLDDT of this model is 95.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate92%
70 to 90Confident: backbone generally right5%
50 to 70Low: treat with caution2%
Below 50Very low: often disordered regions1%

What pLDDT means and how to read it

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover

Subunit structure

Interacts with ATG13, OPRK1, RB1CC1 and ULK1 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Directly interacts with SQSTM1 (By similarity). Interacts with ATG3, ATG7 and MAP15 (PubMed:16704426). Interacts with TECPR2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV and…

Subcellular location

Cytoplasmic vesicle, autophagosome, Cytoplasmic vesicle membrane, Cytoplasm, cytoskeleton, Endoplasmic reticulum, Golgi apparatus

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
5YIPX-ray1.85 ÅA=1-117
7CDBX-ray1.95 ÅA/B=1-117

More AlphaFold highlights

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