DEP domain-containing mTOR-interacting protein (DEPTOR) is a 409-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TB45.
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The mean pLDDT of this model is 79.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269)
Associated component of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR (PubMed:19446321, PubMed:25936805, PubMed:34519268, PubMed:34519269). Associated component of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR (PubMed:19446321, PubMed:34519268). Interacts (via PDZ domain) with…
Lysosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7DKL | X-ray | 1.5 Å | A=21-235 |
| 7PED | X-ray | 1.93 Å | A/B=1-230 |
| 7PE8 | EM | 3.2 Å | I=1-409 |
| 7PE7 | EM | 3.41 Å | I/J=1-409 |
| 7PEB | EM | 3.67 Å | I=1-409 |
| 7PE9 | EM | 3.7 Å | I=1-409 |
| 7PEA | EM | 4.07 Å | I/J=1-409 |
| 7PEC | EM | 4.24 Å | I=1-409 |
| 7OWG | EM | 4.7 Å | O=1-409 |
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