Hepatitis A virus cellular receptor 2 (HAVCR2) is a 301-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TDQ0.
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The mean pLDDT of this model is 71.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair…
Interacts with HMGB1; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (By similarity). Interacts with BAG6 (By similarity). Interacts (phosphorylated) with PIK3R1 and PIK3R2. Interacts (not dependent on its phosphorylation status) with FYN (By similarity). Interacts (in basal state T-cells) with VAV1; AKT1/2, LCP2, ZAP70, SYK, PIK3R1, FYN, SH3BP2 and SH2D2A.…
Cell membrane, Cell junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7M3Z | X-ray | 1.4 Å | A=22-130 |
| 7KQL | X-ray | 1.49 Å | T=13-132 |
| 7M3Y | X-ray | 1.69 Å | B=22-130 |
| 6DHB | X-ray | 1.7 Å | A=24-130 |
| 7M41 | X-ray | 1.79 Å | A/B=22-130 |
| 8TFT | X-ray | 2.3 Å | F/G=22-130 |
| 5F71 | X-ray | 2.4 Å | A/B=22-130 |
| 8TBB | X-ray | 2.5 Å | D=22-131 |
| 6TXZ | X-ray | 3.06 Å | A/B/C/D=22-130 |
| 5DZL | X-ray | 3.4 Å | A/B/C/D=92-121 |
| 8HGJ | EM | 4.82 Å | B=24-130 |
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