RB1-inducible coiled-coil protein 1 (RB1CC1) is a 1594-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TDY2.
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The mean pLDDT of this model is 72.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 51% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of…
Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1 (PubMed:19211835, PubMed:19597335). This complex associates with ATG101 (PubMed:19211835, PubMed:19597335). Interacts with PTK2/FAK1 and PTK2B/PYK2 (PubMed:10769033, PubMed:12221124). Interacts with GABARAP and GABARAPL1 (PubMed:23043107). Interacts with ATG16L1; the interaction is required for ULK1 complex-dependent autophagy…
Nucleus, Cytoplasm, Cytoplasm, cytosol, Preautophagosomal structure, Lysosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7D0E | X-ray | 1.4 Å | A=1490-1594 |
| 9D34 | X-ray | 1.42 Å | A=1490-1594 |
| 8YFL | X-ray | 1.5 Å | A/C=1490-1594 |
| 8YFM | X-ray | 1.5 Å | A/D=1490-1594 |
| 6DCE | X-ray | 1.56 Å | A=1494-1594 |
| 9J54 | X-ray | 1.61 Å | A/C=1490-1594 |
| 7CZG | X-ray | 1.8 Å | A/B/C/D=1490-1594 |
| 7CZM | X-ray | 2.0 Å | A/B=1490-1594 |
| 8YFK | X-ray | 2.0 Å | A/C/E/G=1490-1594 |
| 7EA2 | X-ray | 2.14 Å | A/B=1490-1594 |
| 8YFN | X-ray | 2.3 Å | A/C=1490-1594 |
| 8W6B | X-ray | 2.39 Å | C/D/G/H=1343-1395 |
| 7EAA | X-ray | 2.6 Å | C/D=1286-1395 |
| 6GMA | X-ray | 3.2 Å | A/B/C/D/E/F=1458-1594 |
| 8SOI | EM | 4.2 Å | A/B=1-600 |
| 8SRM | EM | 4.46 Å | A/B=1-640 |
| 8SQZ | EM | 5.85 Å | A/B=1-640 |
| 9C82 | EM | 6.84 Å | F=1-640 |
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