Voltage-dependent L-type calcium channel subunit beta-2 (Cacnb2) is a 655-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8VGC3.
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The mean pLDDT of this model is 66.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:12042350, PubMed:1370480). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (PubMed:12042350, PubMed:1370480). May modulate G protein inhibition (PubMed:11604404, PubMed:12042350, PubMed:1370480). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity)
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:26680202). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (PubMed:26680202). Interacts with CACNA1C (PubMed:15141227). Interacts with RRAD; interaction…
Cell membrane, sarcolemma
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5V2Q | X-ray | 1.7 Å | A=68-189, A=254-476 |
| 1T0H | X-ray | 1.97 Å | A=68-196, B=254-476 |
| 1T0J | X-ray | 2.0 Å | A=68-196, B=254-476 |
| 5V2P | X-ray | 2.0 Å | A=68-189, A=254-476 |
| 3JBR | EM | 4.2 Å | B=68-196, B=254-476 |
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