Voltage-dependent calcium channel gamma-3 subunit (Cacng3) is a 315-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8VHX0.
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The mean pLDDT of this model is 68.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (PubMed:19265014). Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to…
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8C2H | EM | 2.64 Å | E/F/G/H=2-315 |
| 8C2I | EM | 2.7 Å | E/F/G/H=2-315 |
| 8C1Q | EM | 2.82 Å | E/F/G/H=2-315 |
| 8C1P | EM | 2.9 Å | E/F/G/H=2-315 |
| 8P3T | EM | 3.39 Å | E/F/G/H=2-315 |
| 8P3V | EM | 3.53 Å | E/F/G/H=2-315 |
| 8P3W | EM | 3.53 Å | E/F/G/H=2-315 |
| 7TNL | EM | 3.59 Å | A/B/C/D=5-207 |
| 8P3U | EM | 3.77 Å | E/F/G/H=2-315 |
| 7TNP | EM | 3.96 Å | A/B/C/D=5-207 |
| 7TNJ | EM | 4.02 Å | A/B/C/D=5-207 |
| 7TNK | EM | 4.5 Å | A/B/C/D=5-207 |
| 7TNM | EM | 4.74 Å | A/B/C/D=5-207 |
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