Dimethyladenosine transferase 1, mitochondrial (TFB1M) is a 346-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WVM0.
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The mean pLDDT of this model is 91.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome (PubMed:12496758, PubMed:25305075, PubMed:31251801). Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (PubMed:11809803, PubMed:12068295, PubMed:12897151)
Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (PubMed:12068295, PubMed:12897151). Bound to the maturing mtSSU until the late stages of assembly (By similarity)
Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8CSQ | EM | 2.54 Å | 5=1-346 |
| 8CSR | EM | 2.54 Å | 5=1-346 |
| 8CSP | EM | 2.66 Å | 5=1-346 |
| 6AAX | X-ray | 2.99 Å | A/C=28-346 |
| 6AJK | X-ray | 3.0 Å | A=27-346 |
| 8CSU | EM | 3.03 Å | 5=1-346 |
| 9G5B | EM | 3.2 Å | c=1-346 |
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