Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3) is a 1544-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WWN8.
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The mean pLDDT of this model is 67.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 40% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin
Interacts (via SAM domain) with INPPL1/SHIP2
Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Cell projection, lamellipodium, Cell projection, ruffle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7A9B | X-ray | 2.0 Å | A/B=1414-1429 |
| 5JCP | X-ray | 2.1 Å | A/B=906-1107 |
| 7YIR | X-ray | 2.1 Å | A=284-385 |
| 5JD0 | X-ray | 2.3 Å | A/B=906-1107 |
| 7YIS | X-ray | 3.3 Å | A=284-385 |
| 2KG5 | NMR | A=1-80 | |
| 2LNW | NMR | B=1404-1412 |
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